<html><head><meta http-equiv="Content-Type" content="text/html charset=us-ascii"><meta http-equiv="Content-Type" content="text/html charset=us-ascii"><meta http-equiv="Content-Type" content="text/html charset=us-ascii"><meta http-equiv="Content-Type" content="text/html charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">William,<div class=""><br class=""></div><div class="">It is one of the purposes of CANDO - a Chemistry package that runs on top of Clasp to develop molecules (protein kinase inhibitors included) to bind and disrupt protein-protein interfaces.</div><div class=""><br class=""></div><div class="">CANDO (Computer Aided Nanostructure Design and Optimization) is a large collection of functions and classes that allow the programmer to build and design molecules. It runs within Clasp. CANDO is written in C++ and in Clasp Common Lisp.</div><div class=""><br class=""></div><div class="">Clasp is a Common Lisp compiler that uses LLVM as its backend and interoperates with C++.</div><div class=""><br class=""></div><div class="">Clasp is under active development and is available at <a href="http://github.com/drmeister/clasp" class="">github.com/drmeister/clasp</a></div><div class=""><br class=""></div><div class="">CANDO is not yet available on github but will be as soon as I get it to do something useful again (build molecules). CANDO is code that I wrote years ago and it used to be exposed to Python. Then I got fed up with Python and decided to start a little side project to develop a better language (Clasp) to support CANDO.</div><div class=""><br class=""></div><div class="">Best,</div><div class=""><br class=""></div><div class="">.Chris.</div><div class=""><br class=""></div><div class=""><br class=""></div><div class=""><br class=""></div><div class=""><br class=""><div class=""><blockquote type="cite" class=""><div class="">On Jul 5, 2015, at 11:27 AM, William Erbil <<a href="mailto:wkerbil@umn.edu" class="">wkerbil@umn.edu</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><div dir="ltr" class="">Dear Clasp developers,<div class=""><br class=""></div><div class="">Has anyone thought about using Clasp in the development of protein kinase inhibitors that bind at protein-protein interfaces?</div><div class=""><br class=""></div><div class="">Kaya</div></div>
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